All Phenotypes Lepr<Db-2Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lepr^Db-2Btlr
diabetes 2 Bruce Beutler
MGI:3784992

Summary

2 genotypes

Allelic Composition	Lepr^Db-2Btlr/Lepr^Db-2Btlr
Genetic Background	C57BL/6J-Lepr^Db-2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^Db-2Btlr mutation (0 available); any Lepr mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:133633 )

• mice homozygous for this mutation are massively obese

reproductive system

infertility ( J:133633 )

• homozygous mutant mice are infertile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:133633

Allelic Composition	Lepr^Db-2Btlr/Lepr⁺
Genetic Background	C57BL/6J-Lepr^Db-2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^Db-2Btlr mutation (0 available); any Lepr mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:133633 )

• mice heterozygous for this mutation are heavier than wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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