Analysis Tools
mortality/aging
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• embryos die by E15 with significant defects in myeloid development
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hematopoietic system
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• B cells are significantly reduced in irradiated recipient mice 8- and 12- weeks after transfer of fetal liver cells from mutant embryos
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• CD4 T cells are reduced in irradiated recipient mice 8- and 12- weeks after transfer of fetal liver cells from mutant embryos
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• CD8 T cells are reduced in irradiated recipient mice 8- and 12- weeks after transfer of fetal liver cells from mutant embryos
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immune system
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• B cells are significantly reduced in irradiated recipient mice 8- and 12- weeks after transfer of fetal liver cells from mutant embryos
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• CD4 T cells are reduced in irradiated recipient mice 8- and 12- weeks after transfer of fetal liver cells from mutant embryos
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• CD8 T cells are reduced in irradiated recipient mice 8- and 12- weeks after transfer of fetal liver cells from mutant embryos
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• lymph node follicles are disorganized in irradiated recipient mice after transfer of fetal liver cells from mutant embryos
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liver/biliary system
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• fetal liver is about 20% size of normal
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