Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-SOD2)66Ysh
• Allele Name: transgene insertion 66, Ye-Shih Ho
• Allele ID: MGI:3783732
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ACTB-SOD2)66Ysh/0	involves: C3H * C57BL/6	MGI:3783738

Genotype
MGI:3783738

tg1

• Allelic Composition: Tg(ACTB-SOD2)66Ysh/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:89952 )

N • transgenic animals do not display reduced anterior ventricular wall motion and fractional shortening after 1 week of perfusion, whereas wild-type hearts show significant reductions

N • after ischemia and reperfusion, cardiac output (CO) is maintained near baseline levels compared to significantly decreased CO values in wild-type

myocardium necrosis ( J:89952 )

• after ischemia and reperfusion, extent of myocardial necrosis is reduced compared to wild-type littermates

increased cardiac muscle contractility ( J:127776 )

• following 35 minutes of global ischemia and 45 minutes of reperfusion, transgenic hearts display better functional recovery (developed force recovery) than wild-type hearts

decreased myocardial infarct size ( J:127776 )

• infarct size following ischemia and reperfusion is lower than that in wild-type hearts

muscle

myocardium necrosis ( J:89952 )

• after ischemia and reperfusion, extent of myocardial necrosis is reduced compared to wild-type littermates

increased cardiac muscle contractility ( J:127776 )

• following 35 minutes of global ischemia and 45 minutes of reperfusion, transgenic hearts display better functional recovery (developed force recovery) than wild-type hearts

homeostasis/metabolism

decreased myocardial infarct size ( J:127776 )

• infarct size following ischemia and reperfusion is lower than that in wild-type hearts

abnormal lactate dehydrogenase level ( J:127776 )

• LDH release from transgenic hearts during 45 minutes of reperfusion following 35 minutes of global ischemia is half the value released from wild-type hearts following ischemia

cellular

myocardium necrosis ( J:89952 )

• after ischemia and reperfusion, extent of myocardial necrosis is reduced compared to wild-type littermates