Phenotypes associated with this allele

• Allele Symbol: Tg(Gpx1)41Dkd
• Allele Name: transgene insertion 41, Dipak K Das
• Allele ID: MGI:3783719
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Gpx1)41Dkd/0	involves: C3H * C57BL/6	MGI:3783737

Genotype
MGI:3783737

tg1

• Allelic Composition: Tg(Gpx1)41Dkd/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardium necrosis ( J:89952 , J:127782 )

• extent of myocardial necrosis following ischemia and reperfusion is similar to that observed in wild-type (J:89952)

• necrosis following ischemia-reperfusion is significantly decreased compared to controls (J:127782)

abnormal cardiovascular system physiology ( J:127782 )

• following ischemia, creatine kinase release from cardiac tissue is significantly lower during perfusion than release from control hearts after ischemia

increased cardiac muscle contractility ( J:127782 )

• following ischemia and 5 or 20 minutes of reperfusion, myocardial contractile recovery (% of baseline developed force DF) reaches 87% of baseline levels prior to ischemic injury compared to 46% in wild-type hearts

decreased myocardial infarct size ( J:127782 )

• infarct size in ventricle is significantly smaller after 30 minutes of global ischemia in transgenic mice compared to ischemic controls

muscle

myocardium necrosis ( J:89952 , J:127782 )

• extent of myocardial necrosis following ischemia and reperfusion is similar to that observed in wild-type (J:89952)

• necrosis following ischemia-reperfusion is significantly decreased compared to controls (J:127782)

increased cardiac muscle contractility ( J:127782 )

• following ischemia and 5 or 20 minutes of reperfusion, myocardial contractile recovery (% of baseline developed force DF) reaches 87% of baseline levels prior to ischemic injury compared to 46% in wild-type hearts

homeostasis/metabolism

decreased myocardial infarct size ( J:127782 )

• infarct size in ventricle is significantly smaller after 30 minutes of global ischemia in transgenic mice compared to ischemic controls

cellular

myocardium necrosis ( J:89952 , J:127782 )

• extent of myocardial necrosis following ischemia and reperfusion is similar to that observed in wild-type (J:89952)

• necrosis following ischemia-reperfusion is significantly decreased compared to controls (J:127782)