All Phenotypes Stim1<tm1.1Rao> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stim1^tm1.1Rao
targeted mutation 1.1, Anjana Rao
MGI:3778912

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stim1^tm1.1Rao/Stim1^tm1.1Rao	involves: BALB/cJ * C57BL/6 * ICR * SJL	MGI:3783456
hm2	Stim1^tm1.1Rao/Stim1^tm1.1Rao	involves: BALB/cJ * C57BL/6 * SJL	MGI:3783454
cx3	Stim1^tm1.1Rao/Stim1^tm1.1Rao Stim2^tm1.1Rao/Stim2^tm1.1Rao	involves: C57BL/6	MGI:5285572

Allelic Composition	Stim1^tm1.1Rao/Stim1^tm1.1Rao
Genetic Background	involves: BALB/cJ * C57BL/6 * ICR * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stim1^tm1.1Rao mutation (0 available); any Stim1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:133262 )

• 50% of mice that are born alive die by 2 days after birth but die within 2 weeks

perinatal lethality, incomplete penetrance ( J:133262 )

• Background Sensitivity: while Mendelian ratios of embryos are present at E18.5, 38% of mice are born dead on a background with ICR compared to 75% without ICR

growth/size/body

postnatal growth retardation ( J:133262 )

• severe

Allelic Composition	Stim1^tm1.1Rao/Stim1^tm1.1Rao
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stim1^tm1.1Rao mutation (0 available); any Stim1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:133262 )

• all mice that are born alive die by 2 days after birth

perinatal lethality, incomplete penetrance ( J:133262 )

• Background Sensitivity: while Mendelian ratios of embryos are present at E18.5, 75% of mice are born dead compared to 38% on a background involving ICR

cellular

abnormal cell physiology ( J:133262 )

• mouse embryonic fibroblasts treated with thapsigargin fail to exhibit a calcium influx unlike in wild-type cells

Allelic Composition	Stim1^tm1.1Rao/Stim1^tm1.1Rao Stim2^tm1.1Rao/Stim2^tm1.1Rao
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stim1^tm1.1Rao mutation (0 available); any Stim1 mutation (45 available)
Stim2^tm1.1Rao mutation (0 available); any Stim2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to hydrogen peroxide ( J:175075 )

• in mouse embryonic fibroblasts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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