Phenotypes associated with this allele
immune system
|
|
• mice exhibit a milder lymphoproliferation than observed in Stim1tm1Rao/ Stim1tm1Rao Stim2tm1Rao/Stim2tm1Rao Tg(CD4-cre)1Cwi mice
|
|
|
• CD4+ T cells exhibit no calcium influx after depletion with thapsigargin or stimulation with anti-CD3 antibodies and ionomycin unlike wild-type cells
• CD4+ T cells fail to produce IL-2 after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies unlike wild-type cells
|
|
|
• CD4+ T cells fail to produce IL-2 after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies unlike wild-type cells
|
hematopoietic system
|
|
• mice exhibit a milder lymphoproliferation than observed in Stim1tm1Rao/ Stim1tm1Rao Stim2tm1Rao/Stim2tm1Rao Tg(CD4-cre)1Cwi mice
|
|
|
• CD4+ T cells exhibit no calcium influx after depletion with thapsigargin or stimulation with anti-CD3 antibodies and ionomycin unlike wild-type cells
• CD4+ T cells fail to produce IL-2 after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies unlike wild-type cells
|
immune system
|
|
• mice produce more IgE+ B cells than wild-type mice
|
|
|
• mice produce more memory or effector T cells than wild-type mice
• as determined by bone marrow transplant assays, mice exhibit a cell-intrinsic defect in regulatory T cell development
|
|
|
• mice produce more CD11b+ IL-5R+ eosinophils or basophils than wild-type mice
|
|
|
• at 5 to 6 weeks of age, mice exhibit fewer regulatory T cells in the thymus, spleen and lymph nodes compared to wild-type mice due to a cell-intrinsic defect in regulatory T cell development
• while the proportion of regulatory T cells increases with age it remains 10% to 20% of wild-type
|
|
|
• in mice older than 8 weeks
|
|
|
• in mice older than 8 weeks
|
|
|
• T cells undergo reduced proliferation compared to wild-type cells after TCR stimulation
|
|
|
• CD4+ T cells exhibit no calcium influx after depletion with thapsigargin or stimulation with anti-CD3 antibodies and ionomycin unlike wild-type cells
• CD4+ T cells produce almost no IL-2 and very little interferon-gamma after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies compared to wild-type cells
|
|
|
• CD4+ T cells produce very little interferon-gamma after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies compared to wild-type cells
|
|
|
• CD4+ T cells produce almost no IL-2 after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies compared to wild-type cells
|
|
|
• in mice older than 8 weeks
|
|
|
• in mice older than 8 weeks
|
vision/eye
|
|
• in mice older than 8 weeks
|
hematopoietic system
|
|
• T cells undergo reduced proliferation compared to wild-type cells after TCR stimulation
|
|
|
• in mice older than 8 weeks
|
|
|
• mice produce more IgE+ B cells than wild-type mice
|
|
|
• mice produce more memory or effector T cells than wild-type mice
• as determined by bone marrow transplant assays, mice exhibit a cell-intrinsic defect in regulatory T cell development
|
|
|
• mice produce more CD11b+ IL-5R+ eosinophils or basophils than wild-type mice
|
|
|
• at 5 to 6 weeks of age, mice exhibit fewer regulatory T cells in the thymus, spleen and lymph nodes compared to wild-type mice due to a cell-intrinsic defect in regulatory T cell development
• while the proportion of regulatory T cells increases with age it remains 10% to 20% of wild-type
|
|
|
• CD4+ T cells exhibit no calcium influx after depletion with thapsigargin or stimulation with anti-CD3 antibodies and ionomycin unlike wild-type cells
• CD4+ T cells produce almost no IL-2 and very little interferon-gamma after stimulation with phorbol ester PMA and ionomycin or with anti-CD3 and anti-CD28 antibodies compared to wild-type cells
|
integument
|
|
• in mice older than 8 weeks
|
cellular
|
|
• T cells undergo reduced proliferation compared to wild-type cells after TCR stimulation
|
growth/size/body
|
|
• in mice older than 8 weeks
|
Analysis Tools