Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation
(1 available);
any
Ggta1 mutation
(80 available)
Ightm1Jiac mutation
(0 available);
any
Igh mutation
(43 available)
Igktm1Jiac mutation
(0 available);
any
Igk mutation
(25 available)
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immune system
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• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele
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hematopoietic system
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• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation
(1 available);
any
Ggta1 mutation
(80 available)
Ightm1Jiac mutation
(0 available);
any
Igh mutation
(43 available)
Igktm1Jiac mutation
(0 available);
any
Igk mutation
(25 available)
|
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immune system
|
• the frequency of B220+ B cells in the periphery is 10.1% compared to 24.7% in mice with just one Igk knock-in allele
|
hematopoietic system
|
• the frequency of B220+ B cells in the periphery is 10.1% compared to 24.7% in mice with just one Igk knock-in allele
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation
(1 available);
any
Ggta1 mutation
(80 available)
Ightm1Jiac mutation
(0 available);
any
Igh mutation
(43 available)
Igktm1Jiac mutation
(0 available);
any
Igk mutation
(25 available)
|
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hematopoietic system
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• anti-alphaGal IgM is detectable in the sera of mice
• the frequency of B cells expressing anti-alphaGal IgM in the spleen is higher than controls
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• the frequency of B220+ B cells in the periphery is 6.6% compared to 24.7% in mice with just one knock-in allele for Igk and Igh
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• the anti-alphaGal IgM produced by B cells has a lower affinity for antigen than immunoglobulins produced in mice with with no endogenous expression of alphaGal
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immune system
|
• anti-alphaGal IgM is detectable in the sera of mice
• the frequency of B cells expressing anti-alphaGal IgM in the spleen is higher than controls
|
|
• the frequency of B220+ B cells in the periphery is 6.6% compared to 24.7% in mice with just one knock-in allele for Igk and Igh
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• the anti-alphaGal IgM produced by B cells has a lower affinity for antigen than immunoglobulins produced in mice with with no endogenous expression of alphaGal
|