Phenotypes associated with this allele

• Allele Symbol: Cyp11a1^tm2Bcc
• Allele Name: targeted mutation 2, Bon-Chu Chung
• Allele ID: MGI:3778793
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp11a1^tm2Bcc/Cyp11a1^tm2Bcc	Not Specified	MGI:3783625

Genotype
MGI:3783625

hm1

• Allelic Composition: Cyp11a1^tm2Bcc/Cyp11a1^tm2Bcc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:133007 )

• 40% die before 5 weeks of age, probably as a result of issues relating to nursing

• mice surviving weaning have a normal life span

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:133007 )

abnormal adrenal cortex morphology ( J:133007 )

• cortical zonation is perturbed

abnormal adrenal gland zona fasciculata morphology ( J:133007 )

• numerous vacuolar structures

• large oil droplets develop

abnormal adrenal gland zona glomerulosa morphology ( J:133007 )

• numerous vacuolar structures

• large oil droplets develop

enlarged adrenal glands ( J:133007 )

• slight increase in size in young adults becoming very much enlarged by 18 months

abnormal adrenal gland physiology ( J:133007 )

• lower levels of pregnenolone produced

cellular

abnormal mitochondrial morphology ( J:133007 )

• in the adrenal glands

• tubulo-vescicular inner membranes are poorly formed

• cristae not discernable

decreased T cell apoptosis ( J:133007 )

• apoptosis of double positive T cells is blocked

homeostasis/metabolism

abnormal circulating hormone level ( J:133007 )

• morning levels of pregnenolone and aldosterone are normal

decreased circulating corticosterone level ( J:133007 )

• levels in serum are half normal at 2PM and at 7PM

• stressed levels in plasma are half normal

reproductive system

reproductive system phenotype ( J:133007 )

N • sperm counts and sperm motility normal in spite of low gene expression in testes

N • testis histology also appears normal

immune system

decreased T cell apoptosis ( J:133007 )

• apoptosis of double positive T cells is blocked

hematopoietic system

decreased T cell apoptosis ( J:133007 )

• apoptosis of double positive T cells is blocked