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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt6tm1Akis
targeted mutation 1, Andreas Kispert
MGI:3778772
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt6tm1Akis/Wnt6tm1Akis involves: 129P2/OlaHsd MGI:3783428
hm2
 		Wnt6tm1Akis/Wnt6tm1Akis involves: 129P2/OlaHsd * CD-1 * NMRI MGI:5474635


Genotype
MGI:3783428
hm1
Allelic
Composition		 Wnt6tm1Akis/Wnt6tm1Akis
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt6tm1Akis mutation (0 available); any Wnt6 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:132979 )
N
• no obvious abnormality in pituitary development patterns based on examination of makers expression in E18.5




Genotype
MGI:5474635
hm2
Allelic
Composition		 Wnt6tm1Akis/Wnt6tm1Akis
Genetic
Background		 involves: 129P2/OlaHsd * CD-1 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt6tm1Akis mutation (0 available); any Wnt6 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal maternal decidual layer morphology ( J:193969 )
• during decidualization, uterine stromal cell proliferation is impaired with prolonged cell cycle length compared with wild-type cells
abnormal decidualization ( J:193969 )
• defective decidualization with decreased weight and size of implantation sites
• however, stromal-decidual transformation and polyploidization is normal
abnormal embryo implantation ( J:193969 )
• decreased weight and size of implantation sites
• however, initiation of implantation is normal

embryo
abnormal maternal decidual layer morphology ( J:193969 )
• during decidualization, uterine stromal cell proliferation is impaired with prolonged cell cycle length compared with wild-type cells
abnormal decidualization ( J:193969 )
• defective decidualization with decreased weight and size of implantation sites
• however, stromal-decidual transformation and polyploidization is normal

cellular
abnormal cell cycle ( J:193969 )
• during decidualization, uterine stromal cell proliferation is impaired with prolonged cell cycle length compared with wild-type cells
decreased cell proliferation ( J:193969 )
• during decidualization, uterine stromal cell proliferation is impaired with prolonged cell cycle length compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory