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Allele Symbol Allele Name Allele ID |
Gata4tm1(cre)Svs targeted mutation 1, David S Silversides MGI:3778758 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• colonic aganglionosis is caused by a cell-autonomous defect in enteric neural crest cell migration
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• colonic aganglionosis is caused by a cell-autonomous defect in enteric neural crest cell migration
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neural crest cells accumulate in the vicinity of the dorsal neural tube, migrate more slowly, and oscillate rather than persist in their ventrally oriented migration
• neural crest cell speed and directionality at the leading edge of migration streams are impaired
• hindgut colonization by enteric neural crest cells of vagal origin is delayed at E13.5 but not at E15.5
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• neural crest cells accumulate in the vicinity of the dorsal neural tube, migrate more slowly, and oscillate rather than persist in their ventrally oriented migration
• neural crest cell speed and directionality at the leading edge of migration streams are impaired
• hindgut colonization by enteric neural crest cells of vagal origin is delayed at E13.5 but not at E15.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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