Analysis Tools
growth/size/body
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• body weight 13% lower than controls in the first week
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• body weight 20% lower than controls at 20 weeks
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reproductive system
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• females slow to become pregnant
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• males rarely impregnate females and few pups are produced
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behavior/neurological
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• 20% of females show abnormal maternal behavior
• poor nest building behavior
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• poor pup retrieval
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homeostasis/metabolism
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• serum parathyroid hormone levels significantly elevated to levels of controls on a calcium restricted diet
(J:133151)
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• when fed a low calcium diet, mice exhibit reduced calcium transport compared to wild-type mice
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• serum 1,25-dihydroxyvitamin D levels significantly elevated to levels of controls on a calcium restricted diet
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• both intracellular and extracellular calcium is reduced in the epidermis
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• 60% less serum accumulation within 5 to 30 minutes of oral administration
• on low calcium diets, 40-50% less accumulation in 5-30 minutes
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• varies in proportion to dietary calcium
• normal osmolality only on a high calcium diet
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digestive/alimentary system
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• deficient intestinal absorption of calcium
• low dietary calcium causes a 9.6X as opposes to 7.5X increase in calcium absorption
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renal/urinary system
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• varies in proportion to dietary calcium
• normal osmolality only on a high calcium diet
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skeleton
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• femoral mineral density is reduced on a normal calcium diet
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immune system
dermatitis
(
J:133151
)
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• eczematous dermatitis in 20% of adults
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integument
dermatitis
(
J:133151
)
|
• eczematous dermatitis in 20% of adults
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• 80% show alopecia as soon as hair starts to grow
• alopecia improves with age
• 20% of adults with alopecia
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