Phenotypes associated with this allele

• Allele Symbol: Ache^tm1.1Pata
• Allele Name: targeted mutation 1.1, Palmer Taylor
• Allele ID: MGI:3778298
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ache^tm1.1Pata/Ache^tm1.1Pata	involves: 129X1/SvJ	MGI:3841130
hm2	Ache^tm1.1Pata/Ache^tm1.1Pata	involves: 129X1/SvJ * C57BL/6	MGI:3806867

Genotype
MGI:3841130

hm1

• Allelic Composition: Ache^tm1.1Pata/Ache^tm1.1Pata
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal respiration ( J:147483 )

• inspiratory time is shorter than in wild-type mice

• ventilation relative to body size is mildly abnormal

• hypercapnic or hypoxic mice exhibit a blunted response compared to wild-type mice

decreased tidal volume ( J:147483 )

• bambuterol-treated mice exhibit rapid decreased in tidal volume compared to similarly treated wild-type mice

increased tidal volume ( J:147483 )

abnormal respiratory function ( J:147483 )

• mice exhibit increased inspiratory flow compared to in wild-type mice

decreased pulmonary ventilation ( J:147483 )

• bambuterol-treated mice exhibit rapid decrease in expiratory ventilation compared to similarly treated wild-type mice

increased pulmonary ventilation ( J:147483 )

homeostasis/metabolism

decreased body temperature ( J:147483 )

• bambuterol-treated mice exhibit a slow decrease in body temperature compared to similarly treated wild-type mice

increased physiological sensitivity to xenobiotic ( J:147483 )

• bambuterol-treated mice exhibit rapid a decrease in tidal volume and expiratory ventilation, and a slow decrease in body temperature compared to similarly treated wild-type mice

growth/size/body

decreased body weight ( J:147483 )

Genotype
MGI:3806867

hm2

• Allelic Composition: Ache^tm1.1Pata/Ache^tm1.1Pata
• Genetic Background: involves: 129X1/SvJ * C57BL/6

growth/size/body

growth/size/body region phenotype ( J:132775 )

N • growth rate is not as compromised as totally Ache-deficient mice

behavior/neurological

tremors ( J:132775 )

• mice exhibit constant tremors

muscle

muscle weakness ( J:132775 )

• muscle strength is compromised to such an extent as to prevent testing of behavioral and neurological parameters such as coordination

hematopoietic system

abnormal platelet physiology ( J:132775 )

• Ache is absent from surface and interior of platelets, however erythrocytes show normal levels

homeostasis/metabolism

abnormal platelet physiology ( J:132775 )

• Ache is absent from surface and interior of platelets, however erythrocytes show normal levels

reproductive system

reproductive system phenotype ( J:132775 )

N • homozygous mice can reproduce when mated