Phenotypes associated with this allele

• Allele Symbol: Hps5^ru2-Btlr
• Allele Name: ruby-eye 2 Bruce Beutler
• Allele ID: MGI:3778297
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hps5^ru2-Btlr/Hps5^ru2-Btlr	C57BL/6J-Hps5^ru2-Btlr	MGI:3778299

Genotype
MGI:3778299

hm1

• Allelic Composition: Hps5^ru2-Btlr/Hps5^ru2-Btlr
• Genetic Background: C57BL/6J-Hps5^ru2-Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

decreased ear pigmentation ( J:133272 )

• homozygous mutant mice have pink ears

diluted coat color ( J:133272 )

• toffee mutant mice have hypopigmented (gray) fur

abnormal foot pigmentation ( J:133272 )

• homozygous mutant mice have pink feet

decreased tail pigmentation ( J:133272 )

• homozygous mutant mice have pink tails

decreased eye pigmentation ( J:133272 )

• the eyes of homozygous mutants are red

vision/eye

decreased eye pigmentation ( J:133272 )

• the eyes of homozygous mutants are red

craniofacial

decreased ear pigmentation ( J:133272 )

• homozygous mutant mice have pink ears

hearing/vestibular/ear

decreased ear pigmentation ( J:133272 )

• homozygous mutant mice have pink ears

limbs/digits/tail

decreased tail pigmentation ( J:133272 )

• homozygous mutant mice have pink tails

immune system

increased susceptibility to bacterial infection ( J:133272 )

• homozygous mutant mice display enhanced susceptibility to infection by Listeria monocytogenes

increased susceptibility to Herpesvirales infection ( J:133272 )

• homozygous mutant mice exhibit heightened susceptibility to infection by mouse cytomegalovirus (MCMV)

integument

decreased ear pigmentation ( J:133272 )

• homozygous mutant mice have pink ears

diluted coat color ( J:133272 )

• toffee mutant mice have hypopigmented (gray) fur

abnormal foot pigmentation ( J:133272 )

• homozygous mutant mice have pink feet

decreased tail pigmentation ( J:133272 )

• homozygous mutant mice have pink tails

growth/size/body

decreased ear pigmentation ( J:133272 )

• homozygous mutant mice have pink ears