Phenotypes associated with this allele

• Allele Symbol: Tg(Plp1-cre)1Bzal
• Allele Name: transgene insertion 1, Bernard Zalc
• Allele ID: MGI:3778283
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prkar1a^tm2Gsm/Prkar1a^tm2Gsm Tg(Plp1-cre)1Bzal/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2	MGI:3845282

Genotype
MGI:3845282

cn1

• Allelic Composition: Prkar1a^tm2Gsm/Prkar1a^tm2Gsm; Tg(Plp1-cre)1Bzal/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:148464 )

• most mice die before 5 weeks of age

digestive/alimentary system

abnormal small intestine morphology ( J:148464 )

• at time of death, the proximal small intestine is severely distended including the duodenum, sometimes the jejunum, and rarely the ileum

abnormal small intestinal transit time ( J:148464 )

• slowed

craniofacial

abnormal nose morphology ( J:148464 )

• in mild cases, mice exhibit a bulbous nose

short snout ( J:148464 )

• in mild cases

adipose tissue

decreased white adipose tissue amount ( J:148464 )

• at time of death mice have little white adipose tissue

growth/size/body

abnormal nose morphology ( J:148464 )

• in mild cases, mice exhibit a bulbous nose

short snout ( J:148464 )

• in mild cases

decreased body weight ( J:148464 )

• in mild cases, mice exhibit a 30% to 50% reduction in body weight compared to wild-type mice

• in severe cases mice are runted

distended abdomen ( J:148464 )

• in mild cases and more pronounced in severe cases

muscle

muscular atrophy ( J:148464 )

• at time of death

respiratory system

abnormal nose morphology ( J:148464 )

• in mild cases, mice exhibit a bulbous nose

vision/eye

blepharoptosis ( J:148464 )

• in severe cases

dry eyes ( J:148464 )

• in severe cases