Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B*)7Jckr mutation
(1 available)
Tg(Thy1-MAPT*P301S)2541Godt mutation
(0 available)
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nervous system
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• at 12 months, mice exhibit a greater than 50-fold increase in Gallyas+ neurofibrillary pathology compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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• at 12 months, mice exhibit an 18-fold increase in neocortex Tau inclusions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation
(1 available)
Tg(Thy1-MAPT*P301S)2541Godt mutation
(0 available)
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nervous system
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• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
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• mice are unable to extend their hindlimbs when lifted by the tail
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• mice develop tremor at 5-6 months of age
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• mice develop severe paraparesis by 5-6 months of age
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muscle
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• atrophic, angulated muscle fibers are frequently seen in hindlimb skeletal muscle, indicative of denervation atrophy
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• mice develop general muscle weakness at 5-6 months of age
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nervous system
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• large numbers of abnormal tau filaments are seen in the cytoplasm and processes of nerve cells from 5-6 month old mice
• majority of filaments resemble half-twisted ribbons seen in FTDP-17, while a minority resemble paired helical filaments of Alzheimers disease
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• reactive astrocytosis in the motor neurons of the anterior horn of the spinal cord
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• reduction in the number of motor neurons in the ventral gray matter of 6 month old mutants
• 49% reduction in the number of motor neurons in the anterior horn of the spinal cord
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• neuronal cell bodies are often swollen or severely atrophic
• occasionally pyknotic neurons are surrounded by glial cells, suggesting neuronophagia
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vision/eye
immune system
Analysis Tools