Phenotypes associated with this allele

• Allele Symbol: Lgals9^tm1Glp
• Allele Name: targeted mutation 1, Mitsuomi Hirashima
• Allele ID: MGI:3778171
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgals9^tm1Glp/Lgals9^tm1Glp	B6.129S6-Lgals9^tm1Glp	MGI:3809904

Genotype
MGI:3809904

hm1

• Allelic Composition: Lgals9^tm1Glp/Lgals9^tm1Glp
• Genetic Background: B6.129S6-Lgals9^tm1Glp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T-helper 1 cell number ( J:132889 )

• in mice collagen-induced to develop arthritis, the numbers of CD4+ TIM-3+ T-cells are increased compared to in similarly treated wild-type mice

decreased regulatory T cell number ( J:132889 )

• in un-immunized and immunized mice, regulatory T cells numbers are decreased compared to similarly treated wild-type mice and immunization does not lead to an increase the number of T regulatory cells as in wild-type mice

increased susceptibility to induced arthritis ( J:132889 )

• mice exhibit increased susceptibility to collagen-induced arthritis

hematopoietic system

increased T-helper 1 cell number ( J:132889 )

• in mice collagen-induced to develop arthritis, the numbers of CD4+ TIM-3+ T-cells are increased compared to in similarly treated wild-type mice

decreased regulatory T cell number ( J:132889 )

• in un-immunized and immunized mice, regulatory T cells numbers are decreased compared to similarly treated wild-type mice and immunization does not lead to an increase the number of T regulatory cells as in wild-type mice

skeleton

increased susceptibility to induced arthritis ( J:132889 )

• mice exhibit increased susceptibility to collagen-induced arthritis