Phenotypes associated with this allele

• Allele Symbol: Chrng^tm1Vwi
• Allele Name: targeted mutation 1, Veit Witzemann
• Allele ID: MGI:3777606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrng^tm1Vwi/Chrng^tm1Vwi	involves: C57BL/6J	MGI:3777608

Genotype
MGI:3777608

hm1

• Allelic Composition: Chrng^tm1Vwi/Chrng^tm1Vwi
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:132703 )

• however, endplate number is normal in the diaphragm

• at E18.5, acetylcholine receptor density in the diaphragm is reduced 40% compared to in wild-type neurons

• at E18.5, neuronal processes in the diaphragm grow beyond the synaptic band region unlike in wild-type mice

abnormal motor neuron morphology ( J:132703 )

• after E16.5, motor neuron death rate is delayed compared to in wild-type mice

• however, motor neuron death is accelerated postnatally due to receptor type replacement

increased motor neuron number ( J:132703 )

• between E18.5 and P0, mice have 3-fold higher motor neuron levels than wild-type mice

• at P2, mice have twice as many motor neurons as wild-type

abnormal neurite morphology ( J:132703 )

• neurite length does not decrease until after E18.5 unlike in wild-type neurites that exhibit retraction starting at E16.5

• however, by P8 neurite morphology is normal

abnormal dendrite morphology ( J:132703 )

• at E18.5, neuron branching is increased compared to in wild-type mice