All Phenotypes Ret<tm1Heno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1Heno
targeted mutation 1, Hideki Enomoto
MGI:3777553

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1Heno/Ret^tm1Heno	Not Specified	MGI:3783341
ht2	Ret^tm1Heno/Ret^tm2(RET)Jmi	involves: 129X1/SvJ * C57BL/6	MGI:4459065
cn3	Bax^tm1Sjk/Bax^tm1Sjk Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459062
cn4	Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459061
cn5	Ret^tm1Heno/Ret^tm2(RET)Heno Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459060

Allelic Composition	Ret^tm1Heno/Ret^tm1Heno
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

abnormal motor neuron innervation pattern ( J:132854 )

• peroneal muscles totally lack both motor and sensory innervation in 42% of homozygotes

• 58% with normal peroneal innervation or with innervation absent only in the superficial peroneal muscles

decreased motor neuron number ( J:132854 )

• elevated apoptosis of motor neurons between 13.5 and E15.5

muscle

abnormal hypaxial muscle morphology ( J:132854 )

abnormal gastrocnemius morphology ( J:132854 )

• reduced in size but with normal motor innervation

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

limbs/digits/tail

abnormal gastrocnemius morphology ( J:132854 )

• reduced in size but with normal motor innervation

Allelic Composition	Ret^tm1Heno/Ret^tm2(RET)Jmi
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (53 available)
Ret^tm2(RET)Jmi mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:159854 )

postnatal lethality, incomplete penetrance ( J:159854 )

• 23% of mice die between P5 and P31

digestive/alimentary system

abnormal defecation ( J:159854 )

• mice exhibit decreased stool frequency compared with control mice

abnormal feces composition ( J:159854 )

• mice exhibit wet stool weight and water stool content compared with control mice

renal/urinary system

renal/urinary system phenotype ( J:159854 )

N	• mice exhibit normal kidney development

nervous system

nervous system phenotype ( J:159854 )

N	• mice exhibit normal motor innervation

absent enteric neurons ( J:159854 )

• in 8 of 21 mice

embryo

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

growth/size/body

decreased body weight ( J:159854 )

postnatal growth retardation ( J:159854 )

cellular

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ret^tm1Heno mutation (0 available); any Ret mutation (53 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (53 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:159854 )

• tamoxifen-treated mice exhibit loss of enteric neurons unlike similarly treated control mice (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

Allelic Composition	Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (53 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (53 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal defecation ( J:159854 )

• tamoxifen-treated mice exhibit decreased stool frequency compared with control mice

• 2 to 5 tamoxifen-treated mice exhibit hard feces that accumulates in the distal colon unlike in control mice

abnormal feces composition ( J:159854 )

• tamoxifen-treated mice exhibit wet stool weight and water stool content compared with control mice

growth/size/body

decreased body weight ( J:159854 )

• in tamoxifen-treated mice

nervous system

abnormal enteric neuron morphology ( J:159854 )

• 40% of tamoxifen-treated mice exhibit reduced enteric neurons compared with similarly treated control mice (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

• tamoxifen-treated mice exhibit fewer NOS-expressing neurons compared to in control mice

• however, 60% of tamoxifen-treated mice exhibit normal enteric nervous system development

Allelic Composition	Ret^tm1Heno/Ret^tm2(RET)Heno Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (53 available)
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (53 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:159854 )

• tamoxifen-treated mice exhibit fewer enteric neurons than in similarly controls (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

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