Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Bwh mutation
(0 available);
any
Dab1 mutation
(77 available)
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nervous system
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• mice exhibit mild ectopias
• CDP+ neurons are more widely dispersed than in wild-type
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• Purkinje cells are displaced from the normal monolayer in several folia
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• the vermis to whole brain ratio is smaller than in wild-type mice
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behavior/neurological
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N |
• mice exhibit normal behavior
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Allelic
Composition |
Dab1tm1Bwh/Dab1+
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Genetic
Background |
involves: 129S4/SvJaeSor * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Bwh mutation
(0 available);
any
Dab1 mutation
(77 available)
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nervous system
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• foliation is not as severely affected as in homozygous mice
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• cerebellar size is not as reduced as in homozygous mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Dbo mutation
(4 available);
any
App mutation
(89 available)
Dab1tm1Bwh mutation
(0 available);
any
Dab1 mutation
(77 available)
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nervous system
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• the cerebellum volume is not as small as in Dab1tm1Bwh homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Dbo mutation
(4 available);
any
App mutation
(89 available)
Dab1tm1Bwh mutation
(0 available);
any
Dab1 mutation
(77 available)
|
|
|
nervous system
|
|
• the cerebellum volume is not as small as in Dab1tm1Bwh homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Bwh mutation
(0 available);
any
Dab1 mutation
(77 available)
Tg(APPSWE)2576Kha mutation
(5 available)
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nervous system
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• the loss of divisions between some folia is apparent
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• the vermis to whole brain ratio is smaller than in Dab1tm1Bwh homozygotes
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Analysis Tools