Analysis Tools
mortality/aging
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• fail to survive beyond 14 weeks of age
|
behavior/neurological
|
• progressive loss of motor coordination
|
|
• progressive loss of activity
|
nervous system
|
• extensive apoptosis of neurons in the striatum and cerebellum develops
|
astrocytosis
(
J:132627
)
|
• extensive infiltration of astrocytes in the striatum
|
hematopoietic system
|
• loss of cellularity related to increase in apoptotic cells
|
|
• by apoptosis
|
|
• loss with age in the spleen, thymus, and bone marrow
|
|
• preferential loss of pro- and pre-B cells
• increased apoptosis
|
|
• increased susceptibility to absence of cytokines
|
|
• equal to single positive cell loss
|
|
• equal to double positive cell loss
|
immune system
|
• by apoptosis
|
|
• loss with age in the spleen, thymus, and bone marrow
|
|
• preferential loss of pro- and pre-B cells
• increased apoptosis
|
|
• increased susceptibility to absence of cytokines
|
|
• equal to single positive cell loss
|
|
• equal to double positive cell loss
|
cellular
|
• extensive apoptosis of neurons in the striatum and cerebellum develops
|
