Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf1tm1Oono mutation
(1 available);
any
Slamf1 mutation
(24 available)
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immune system
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• splenocytes and DCs from the mutant mice permitted IC-B strain measle virus entry and replication in vitro, however, measle virus growth was not supported in vivo
• normal level of IL-4 and IFN-gamma from CD4+
• normal production of TNF-alpha and NO from peritoneal macrophages
• normal cellular composition of splenocytes
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immune system
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• lymphocytes from measle virus infected double mutant show proliferation inhibition when stimulated with ConA
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• double mutant mice permitted the in vivo growth of measle virus after i.p. or intranasal inoculation, however, on the contrary to expectation, growth of IC-B strain measle virus was not enhanced in splenocytes form double mutant compared with those from the single mutant, Ifnar1+/Ifnar1+, Slamf1tm1Oono/Slamf1tm1Oono, splenocytes
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hematopoietic system
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• lymphocytes from measle virus infected double mutant show proliferation inhibition when stimulated with ConA
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Analysis Tools