Phenotypes associated with this allele

• Allele Symbol: Cd3e^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3776477
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd3e^m1Btlr/Cd3e^m1Btlr	C57BL/6J-Cd3e^m1Btlr	MGI:3776479
hm2	Cd3e^m1Btlr/Cd3e^m1Btlr	involves: C57BL/6J	MGI:5429180

Genotype
MGI:3776479

hm1

• Allelic Composition: Cd3e^m1Btlr/Cd3e^m1Btlr
• Genetic Background: C57BL/6J-Cd3e^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:132486 )

• homozygous mutant thymocytes undergo apoptosis at a higher rate than do those of wild-type mice

abnormal thymus morphology ( J:132486 )

• thymi of homozygous mutant mice are structurally abnormal

small thymus ( J:132486 )

• homozygous mutant mice have very small thymi

arrested T cell differentiation ( J:132486 )

• development of mutant thymocytes is arrested at the CD44⁺CD25^-, double negative 3 (DN3) stage

absent T cells ( J:132486 )

• homozygous mutants lack peripheral T lymphocytes

• no CD4⁺CD8⁺ T cells are present in mutant thymi

immune system

increased T cell apoptosis ( J:132486 )

• homozygous mutant thymocytes undergo apoptosis at a higher rate than do those of wild-type mice

abnormal thymus morphology ( J:132486 )

• thymi of homozygous mutant mice are structurally abnormal

small thymus ( J:132486 )

• homozygous mutant mice have very small thymi

arrested T cell differentiation ( J:132486 )

• development of mutant thymocytes is arrested at the CD44⁺CD25^-, double negative 3 (DN3) stage

absent T cells ( J:132486 )

• homozygous mutants lack peripheral T lymphocytes

• no CD4⁺CD8⁺ T cells are present in mutant thymi

behavior/neurological

seizures ( J:132486 )

• some homozygous mutants older than 9 months appear to experience epileptic-like seizures

nervous system

seizures ( J:132486 )

• some homozygous mutants older than 9 months appear to experience epileptic-like seizures

cellular

increased T cell apoptosis ( J:132486 )

• homozygous mutant thymocytes undergo apoptosis at a higher rate than do those of wild-type mice

endocrine/exocrine glands

abnormal thymus morphology ( J:132486 )

• thymi of homozygous mutant mice are structurally abnormal

small thymus ( J:132486 )

• homozygous mutant mice have very small thymi

Genotype
MGI:5429180

hm2

• Allelic Composition: Cd3e^m1Btlr/Cd3e^m1Btlr
• Genetic Background: involves: C57BL/6J

immune system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice