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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh3H9)41Mwg
transgene insertion 41, Martin Weigert
MGI:3776392
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Igh3H9)41Mwg/? involves: C57BL/6 * SJL MGI:3776425


Genotype
MGI:3776425
tg1
Allelic
Composition		 Tg(Igh3H9)41Mwg/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh3H9)41Mwg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:119625 )
• B cells fail to differentiate into immunoglobulin secreting cells
decreased IgD level ( J:119625 )
• splenic B cells do not express IgD on their surface
increased anti-single stranded DNA antibody level ( J:119625 )
• 63% of IgM-positive B cells bind single stranded DNA
• however, there is no increase in the sera of anti-DNA antibodies

hematopoietic system
abnormal B cell differentiation ( J:119625 )
• B cells fail to differentiate into immunoglobulin secreting cells
decreased IgD level ( J:119625 )
• splenic B cells do not express IgD on their surface




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory