Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr1tm1.1Jlab mutation
(0 available);
any
Flvcr1 mutation
(30 available)
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mortality/aging
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• Background Sensitivity: dead but morphologically identifiable homozygous embryos are found E12.5, while on a mixed background, mutants surviving past E7.5 are alive and indistinguishable from littermates at E12.5
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limbs/digits/tail
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• Background Sensitivity: limbs are abnormal but this phenotype is less apparent than on a mixed background and when death occurs prior to E14.5
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craniofacial
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• Background Sensitivity: defects are observed but are less apparent than on mixed background and when death occurs prior to E14.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr1tm1.1Jlab mutation
(0 available);
any
Flvcr1 mutation
(30 available)
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growth/size/body
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• cardiomegaly observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal
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• by 4 weeks of age, mice are runted, after cre induction at 1 week postnatal
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• observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal
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cardiovascular system
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• cardiomegaly observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal
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hematopoietic system
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• bone marrow shows block in erythroid maturation at proerythroblast stage; this is also observed in liver and spleen
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• mice develop pure red cell aplasia (PRCA)
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• observed at 6 weeks of age, following cre induction at 1 week postnatal
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• mice show reticulocytopenia by 6 weeks of age, following cre induction at 1 week postnatal
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• enlarged spleens have expanded interfollicular regions
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• observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal
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immune system
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• enlarged spleens have expanded interfollicular regions
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• observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal
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limbs/digits/tail
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• by 4 weeks of age, mice have pale paws, after cre induction at 1 week postnatal
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Allelic Composition |
Flvcr1tm1.1Jlab/Flvcr1+
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 * DBA/2 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr1tm1.1Jlab mutation
(0 available);
any
Flvcr1 mutation
(30 available)
|
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normal phenotype
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• indistinguishable from controls
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