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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
WwoxGt(XG218)Byg
gene trap XG218, BayGenomics
MGI:3775954
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
WwoxGt(XG218)Byg/WwoxGt(XG218)Byg involves: 129P2/OlaHsd MGI:3801316


Genotype
MGI:3801316
hm1
Allelic
Composition
WwoxGt(XG218)Byg/WwoxGt(XG218)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
WwoxGt(XG218)Byg mutation (0 available); any Wwox mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increased death rate beginning at 3-4 months of age
• increased death rate beginning at 3-4 months of age
• during the first 18 months of the study, 23% of mutants died compared to 0% of wild-type

reproductive system
• testes have high numbers of atrophic seminiferous tubules

neoplasm
• females exhibit a high incidence of spontaneous B-cell lymphomas
• lymphomas are more invasive than the few lymphomas that develop in wild-type females, and show a high degree of infiltration of multiple organs such as pancreas and mesenteric lymph nodes
• females exhibit an increase in the incidence of malignant neoplasias

endocrine/exocrine glands
• testes have high numbers of atrophic seminiferous tubules





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory