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Allele Symbol Allele Name Allele ID |
Ifnlr1tm1Palu targeted mutation 1, Soren R Paludan MGI:3775762 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the murine model for genital herpes, in which local administration of TLR3 and TLR9 ligands induces a strong antiviral response, viral titers were significantly higher in mutant mice and developed signs of disease to a higher extent than did the wild-type
• mutant mice were otherwise indistinguishable from wild-type mice with respect to clearance of a panel of different viruses
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice infected with the Urbani strain of severe acute respiratory syndrome coronavirus (SARS-CoV) or a recombinant isogenic mouse-adapted SARS-CoV (rMA15) that contains six virulence modifying mutations show no increase in susceptibility, pathogenesis, or histological outcomes to infection compared to wild-type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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