All Phenotypes Igkrs<tm1Nemz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igkrs^tm1Nemz
targeted mutation 1, David Nemazee
MGI:3775730

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igkrs^tm1Nemz/Igkrs^tm1Nemz	B6.129-Igkrs^tm1Nemz	MGI:3776232
cx2	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(BCL2)22Wehi/?	involves: 129 * C57BL	MGI:3776233
cx3	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(UBC-scFv)2Nemz/?	involves: 129 * C57BL/6 * DBA/2	MGI:3776235

Allelic Composition	Igkrs^tm1Nemz/Igkrs^tm1Nemz
Genetic Background	B6.129-Igkrs^tm1Nemz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkrs^tm1Nemz mutation (1 available); any Igkrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased immature B cell number ( J:132125 )

• there is about a 40% reduction in immature B cells that express lambda chain

• immature B cells expressing kappa chain have normal numbers

abnormal immunoglobulin light chain V-J recombination ( J:132125 )

• no recombination occurs between the RS domain and other domains within the Igk locus

decreased mature B cell number ( J:132125 )

• there is about a 40% reduction in mature B cells that express lambda chain

• immature B cells expressing kappa chain have normal numbers

hematopoietic system

decreased immature B cell number ( J:132125 )

• there is about a 40% reduction in immature B cells that express lambda chain

• immature B cells expressing kappa chain have normal numbers

abnormal immunoglobulin light chain V-J recombination ( J:132125 )

• no recombination occurs between the RS domain and other domains within the Igk locus

decreased mature B cell number ( J:132125 )

• there is about a 40% reduction in mature B cells that express lambda chain

• immature B cells expressing kappa chain have normal numbers

Allelic Composition	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(BCL2)22Wehi/?
Genetic Background	involves: 129 * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkrs^tm1Nemz mutation (1 available); any Igkrs mutation (1 available)
Tg(BCL2)22Wehi mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased anti-double stranded DNA antibody level ( J:132125 )

• there is a significant increase in IgG and IgM antibodies that bind DNA in the sera of 5 month old mice

Allelic Composition	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(UBC-scFv)2Nemz/?
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkrs^tm1Nemz mutation (1 available); any Igkrs mutation (1 available)
Tg(UBC-scFv)2Nemz mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell clonal deletion ( J:132125 )

• there is slight increase in autoreactive B cells expressing kappa chain that escape selection in the bone marrow

decreased immature B cell number ( J:132125 )

• there are fewer B cells expressing lambda chain in the bone marrow

decreased mature B cell number ( J:132125 )

• there are fewer B cells expressing lambda chain in the spleen

hematopoietic system

abnormal B cell clonal deletion ( J:132125 )

• there is slight increase in autoreactive B cells expressing kappa chain that escape selection in the bone marrow

decreased immature B cell number ( J:132125 )

• there are fewer B cells expressing lambda chain in the bone marrow

decreased mature B cell number ( J:132125 )

• there are fewer B cells expressing lambda chain in the spleen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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