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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrbtm1(Tcrb)Fwa
targeted mutation 1, Frederick W Alt
MGI:3775389
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrbtm1(Tcrb)Fwa/Tcrbtm1(Tcrb)Fwa involves: 129 MGI:3775397


Genotype
MGI:3775397
hm1
Allelic
Composition		 Tcrbtm1(Tcrb)Fwa/Tcrbtm1(Tcrb)Fwa
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1(Tcrb)Fwa mutation (0 available); any Tcrb mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:131995 )
• thymocytes and splenocytes completely lack cell surface expression of Vbeta14 segment
• recombination of the knocked in gene segments occurs in T but not B- cells
• rearrangement occurred 80% to 90% of the time as opposed to 5% of the time for the endogenous gene segment

immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:131995 )
• thymocytes and splenocytes completely lack cell surface expression of Vbeta14 segment
• recombination of the knocked in gene segments occurs in T but not B- cells
• rearrangement occurred 80% to 90% of the time as opposed to 5% of the time for the endogenous gene segment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory