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Allele Symbol Allele Name Allele ID |
Tg(KRT14-Angpt1)1Gdy transgene insertion 1, George D Yancopoulos MGI:3775303 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased size of capillaries in the dermis
• significant decrease in the number of very large (greater than 10^4 micrometers squared) but only a slight, non-significant decrease in the number of large (greater than 5 x 10^3 micrometers squared) compared to transgenic mice that express Apln
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dermal capillaries and venules are more numerous, more highly branched and in some cases enlarged
(J:50482)
• changes to capillaries and venules vary in different areas of the skin with skin from the tip of the ear consistently affected
(J:50482)
• increased size of capillaries in the dermis
(J:131824)
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• dermal capillaries are more highly branched
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• however, no signs of plasma leakage, edema, or erythrocyte extravasation are detected
• many more large vessels are present in the skin
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• dermal capillaries and venules are more numerous, more highly branched and in some cases enlarged
• changes to capillaries and venules vary in different areas of the skin with skin from the tip of the ear consistently affected
• skin from the tip of the ear contains some prominently enlarged, abnormally shaped (resulting from vascular varicosities) venules
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• vascular varicosities are seen in some venules in skin from the tip of the ear
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• many more large vessels are present in the skin
• however, no signs of plasma leakage, edema, or erythrocyte extravasation are detected
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• skin become progressively redder in mice from 2 weeks to 2 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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