Phenotypes associated with this allele

• Allele Symbol: Rictor^{Gt(RRR347)Byg}
• Allele Name: gene trap RRR347, BayGenomics
• Allele ID: MGI:3775093
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rictor^Gt(RRR347)Byg/Rictor^Gt(RRR347)Byg	involves: 129P2/OlaHsd	MGI:3802635
hm2	Rictor^Gt(RRR347)Byg/Rictor^Gt(RRR347)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3777012
cx3	Pten^tm1Rps/Pten^+ Rictor^Gt(RRR347)Byg/Rictor^+	involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6	MGI:4848133

Genotype
MGI:3802635

hm1

• Allelic Composition: Rictor^{Gt(RRR347)Byg}/Rictor^{Gt(RRR347)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137592 )

• mice die at around E10.5

embryo

embryonic growth retardation ( J:137592 )

abnormal placenta morphology ( J:137592 )

• the interface between the trophoblast giant cell layer and the labyrinth is somewhat disorganized

thick placenta labyrinth ( J:137592 )

• thicker than in wild-type mice

growth/size/body

embryonic growth retardation ( J:137592 )

Genotype
MGI:3777012

hm2

• Allelic Composition: Rictor^{Gt(RRR347)Byg}/Rictor^{Gt(RRR347)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:113443 )

• mice die around E10.5 - E12.5

Genotype
MGI:4848133

cx3

• Allelic Composition: Pten^tm1Rps/Pten⁺; Rictor^{Gt(RRR347)Byg}/Rictor⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6

mortality/aging

extended life span ( J:144810 )

• double mutants tend to live longer than single heterozygous Pten mice

endocrine/exocrine glands

prostate gland hyperplasia ( J:144810 )

♂ • prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

reproductive system

prostate gland hyperplasia ( J:144810 )

♂ • prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

neoplasm

decreased tumor incidence ( J:144810 )

• mutants are protected from prostate cancer development: only 1 of 10 double mutants developed a tumor compared to 5 of 9 single heterozygous Pten mice