Phenotypes associated with this allele

• Allele Symbol: Trp53^tm2Att
• Allele Name: targeted mutation 2, Laura D Attardi
• Allele ID: MGI:3775090
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm2Att/Trp53^tm2Att	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	MGI:3777013
cn2	Tg(CMV-cre)1Cgn/0 Trp53^tm2Att/Trp53^+	involves: 129S4/SvJae * BALB/cJ	MGI:3777014

Genotype
MGI:3777013

cn1

• Allelic Composition: Trp53^tm2Att/Trp53^tm2Att
• Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:131856 )

• cre-transfected MEFs display cell cycle arrest in the absence of DNA damage

decreased cellular sensitivity to ultraviolet irradiation ( J:131856 )

• MEFs transfected with adenoviral cre fail to induce apoptosis in response to UVC

early cellular replicative senescence ( J:131856 )

• cre-transfected MEFs display markers of cellular senescence within 4 days of transfection which are not seen in controls (cre-transfected-MEFs homozygous for Trp53^tm5Tyj)

Genotype
MGI:3777014

cn2

• Allelic Composition: Tg(CMV-cre)1Cgn/0; Trp53^tm2Att/Trp53⁺
• Genetic Background: involves: 129S4/SvJae * BALB/cJ

mortality/aging

prenatal lethality, complete penetrance ( J:131856 )

• no viable adults are found and no postnatal lethality is detected suggesting mice die in the prenatal period