About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Espl1tm2Pzg
targeted mutation 2, Pumin Zhang
MGI:3775062
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Espl1tm2Pzg/Espl1tm2Pzg involves: 129S7/SvEvBrd MGI:3776847
cn2
 		Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:3776851


Genotype
MGI:3776847
hm1
Allelic
Composition		 Espl1tm2Pzg/Espl1tm2Pzg
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm2Pzg mutation (0 available); any Espl1 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3776851
cn2
Allelic
Composition		 Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm2Pzg mutation (0 available); any Espl1 mutation (95 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogonia morphology ( J:131838 )
• lack spermatogonia
absent primordial germ cells ( J:131838 )
• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
decreased primordial germ cell proliferation ( J:131838 )
• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc
small testis ( J:131838 )
• significantly smaller testes at 6 wks of age
abnormal spermatogenesis ( J:131838 )
• no sign of spermatogenesis detected at 2 wks of age, due to spermatogonia cell depletion
abnormal spermatid morphology ( J:131838 )
• absence of spermatids in seminiferous tubules
abnormal spermatocyte morphology ( J:131838 )
• absence of spermatocytes in seminiferous tubules
infertility ( J:131838 )
• both sexes are sterile

cellular
abnormal spermatid morphology ( J:131838 )
• absence of spermatids in seminiferous tubules
abnormal spermatocyte morphology ( J:131838 )
• absence of spermatocytes in seminiferous tubules
abnormal spermatogonia morphology ( J:131838 )
• lack spermatogonia
absent primordial germ cells ( J:131838 )
• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
abnormal centrosome morphology ( J:131838 )
• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
aneuploidy ( J:131838 )
• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
abnormal mitosis ( J:131838 )
• abnormal metaphase configuration of mutant PGCs at 13.5 dpc
• precocious sister chromatid separation and arrest of PGCs in mitosis due to spindle checkpoint activation
increased mitotic index ( J:131838 )
• significantly higher mitotic indices in mutant PGCs than controls at 12.5, 13.5, and 14.5 dpc
decreased primordial germ cell proliferation ( J:131838 )
• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc

embryo
abnormal gonadal ridge morphology ( J:131838 )
• higher levels of activated caspase-3, p53, and Bax in extracts of 13.5 dpc mutant genital ridges than in controls, suggesting p53-related apoptosis of mutant PGCs

endocrine/exocrine glands
small testis ( J:131838 )
• significantly smaller testes at 6 wks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory