All Phenotypes Notch1<tm2.1Pst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch1^tm2.1Pst
targeted mutation 2.1, Pamela Stanley
MGI:3774554

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Notch1^tm2Pst/Notch1^tm2.1Pst	B6.Cg-Notch1^tm2.1Pst	MGI:3775287
ht2	Notch1^tm2Pst/Notch1^tm2.1Pst	involves: 129/Sv * C57BL/6 * SJL	MGI:3775288
cx3	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Notch1^tm2.1Pst/Notch1⁺	involves: 129/Sv * C57BL/6J * DBA/2 * SJL	MGI:7640235

Allelic Composition	Notch1^tm2Pst/Notch1^tm2.1Pst
Genetic Background	B6.Cg-Notch1^tm2.1Pst

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2.1Pst mutation (0 available); any Notch1 mutation (116 available)
Notch1^tm2Pst mutation (0 available); any Notch1 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131563 )

• mice die at E10

embryo

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 13 to 17 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes

growth/size/body

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 13 to 17 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes

Allelic Composition	Notch1^tm2Pst/Notch1^tm2.1Pst
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131563 )

• mice die around E12

embryo

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes and 13 to 17 in Notch1^tm2.1Pst homozygotes

decreased embryo size ( J:131563 )

• at E10.5

abnormal embryonic neuroepithelium morphology ( J:131563 )

• at E10.5

cardiovascular system

abnormal vasculogenesis ( J:131563 )

• at E10.5 mice are anemic due to defects in vasculogenesis

abnormal heart development ( J:131563 )

• at E10.5, mice exhibit an underdeveloped heart loop

nervous system

abnormal embryonic neuroepithelium morphology ( J:131563 )

• at E10.5

hematopoietic system

anemia ( J:131563 )

• at E10.5 mice are anemic due to defects in vasculogenesis

growth/size/body

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes and 13 to 17 in Notch1^tm2.1Pst homozygotes

decreased embryo size ( J:131563 )

• at E10.5

Allelic Composition	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Notch1^tm2.1Pst/Notch1⁺
Genetic Background	involves: 129/Sv * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eogt^tm1.2Okaj mutation (0 available); any Eogt mutation (44 available)
Notch1^tm2.1Pst mutation (0 available); any Notch1 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single homozygote, with even greater vessel branching and number of filopodia

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single homozygote, with even greater vessel branching and number of filopodia

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