All Phenotypes Gja8<L1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gja8^L1
lens mutation 1
MGI:3774321

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja8^L1/Gja8^L1	involves: C3H/HeJ * C57BL/6J	MGI:3811918
ht2	Gja8^L1/Gja8⁺	involves: C3H/HeJ * C57BL/6J	MGI:3811919
ht3	Gja8^L1/Gja8^tm1Scr	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J	MGI:3811921
cx4	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr	involves: 129 * C3H/HeJ * C57BL/6J	MGI:3811922
cx5	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8⁺	involves: 129S4/SvJae * C3H/HeJ * C57BL/6J	MGI:3811920

Allelic Composition	Gja8^L1/Gja8^L1
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

ruptured lens capsule ( J:108522 )

• posterior capsule ruptures

lens vacuoles ( J:108522 )

• vacuole formation

abnormal lens fiber morphology ( J:108522 )

• disorganized

• large cystic lumen forms between posterior primary fiber cells and anterior epithelium at E15.5

• primary fiber cells fail to elongate normally

cataract ( J:108522 )

microphthalmia ( J:108522 )

Allelic Composition	Gja8^L1/Gja8⁺
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

ruptured lens capsule ( J:108522 )

• posterior capsule ruptures

lens vacuoles ( J:108522 )

• vacuole formation

abnormal lens fiber morphology ( J:108522 )

• disorganized

cataract ( J:108522 )

microphthalmia ( J:108522 )

• eyes are 30% the size of controls at weaning

Allelic Composition	Gja8^L1/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• lack cysts in lens

total cataract ( J:108522 )

• whole cataracts

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr
Genetic Background	involves: 129 * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:108522 )

• cystic lumen

nuclear cataract ( J:108522 )

• nuclear rather than whole cataracts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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