Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(GFAP-cre/ERT2)505Fmv transgene insertion 505, Flora M Vaccarino MGI:3774167 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no increased anxiety in tail suspension, forced swimming, or sucrose preference tests after exposure to chronic unpredictable stress (CUS)
• normal anxiety levels in tail suspension, forced swimming, and sucrose preference tests without exposure to chronic unpredictable stress (CUS)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 16 weeks of age, concentration of the aspartoacylase substrate N-acetyl-L-aspartate (NAA) in brain in tamoxifen-treated mice is 55% below that in tamoxifen-treated control homozygous Aspanur7 mice, indicating partial reversal of increased brain NAA levels seen in Canavan disease model Aspanur7 mice
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• the extent of cerebellar vacuolation in tamoxifen-treated mice is not different from that seen in homozygous Aspanur7 mice
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• accelerating rotarod retention time is increased by 1 week after completion of tamoxifen administration and remains elevated through 7 additional weeks compared to homozygous Aspanur7 mice, indicating improved motor function
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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