Phenotypes associated with this allele

• Allele Symbol: Mbnl2^{Gt(RRK149)Byg}
• Allele Name: gene trap RRK149, BayGenomics
• Allele ID: MGI:3774137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbnl2^Gt(RRK149)Byg/Mbnl2^Gt(RRK149)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3811717

Genotype
MGI:3811717

hm1

• Allelic Composition: Mbnl2^{Gt(RRK149)Byg}/Mbnl2^{Gt(RRK149)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle fiber morphology ( J:130160 )

• muscle fibers exhibit an increased in centrally localized nuclei, increased heterogeneity compared to wild-type fibers

decreased skeletal muscle fiber size ( J:130160 )

• muscle fibers exhibit an overall reduction in fiber size compared to wild-type fibers

centrally nucleated skeletal muscle fibers ( J:130160 )

• muscle fibers exhibit centrally localized nuclei

skeletal muscle interstitial fibrosis ( J:130160 )

• mice exhibit an increase in collagen and fibrosis in muscle fibers compared to in wild-type fibers

impaired muscle relaxation ( J:130160 )

• mice exhibit myotonia that progressively decreases upon repeated muscle contractions

skeleton

lordosis ( J:130160 )