Phenotypes associated with this allele

• Allele Symbol: Agtpbp1^pcd-Btlr
• Allele Name: Purkinje cell degeneration Bruce Beutler
• Allele ID: MGI:3774134
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agtpbp1^pcd-Btlr/Agtpbp1^pcd-Btlr	C57BL/6J-Agtpbp1^pcd-Btlr	MGI:3784975

Genotype
MGI:3784975

hm1

• Allelic Composition: Agtpbp1^pcd-Btlr/Agtpbp1^pcd-Btlr
• Genetic Background: C57BL/6J-Agtpbp1^pcd-Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:133627 )

♂ • homozygous males have reduced numbers of sperm cells

teratozoospermia ( J:133627 )

♂ • sperm cells of male homozygotes are abnormally shaped

male infertility ( J:133627 )

♂ • male mice homozygous for this mutation are sterile

nervous system

nervous system phenotype ( J:133627 )

N • homozygous drunk and wild-type mice recover at the same rate following sciatic nerve crush injury

Purkinje cell degeneration ( J:133627 )

• degeneration of cerebellar Purkinje cells of homozygous mutant mice is first observable when the mice are approximately 3 weeks of age and progresses rapidly until virtually all cells are lost by 7 weeks

retina photoreceptor degeneration ( J:133627 )

• degeneration of photoreceptor cells of homozygous mutants begins at about 6 weeks of age

behavior/neurological

ataxia ( J:133627 )

• homozygous drunk mice exhibit severe ataxia of gait

vision/eye

retina photoreceptor degeneration ( J:133627 )

• degeneration of photoreceptor cells of homozygous mutants begins at about 6 weeks of age

cellular

oligozoospermia ( J:133627 )

♂ • homozygous males have reduced numbers of sperm cells

teratozoospermia ( J:133627 )

♂ • sperm cells of male homozygotes are abnormally shaped