Phenotypes associated with this allele

• Allele Symbol: Spi1^tm3Dgt
• Allele Name: targeted mutation 3, Daniel G Tenen
• Allele ID: MGI:3773989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spi1^tm3Dgt/Spi1^tm3Dgt	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3793731

Genotype
MGI:3793731

hm1

• Allelic Composition: Spi1^tm3Dgt/Spi1^tm3Dgt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-negative T cell number ( J:131217 )

• the number of DN3 decreased 4-fold compared to in wild-type mice

increased double-negative T cell number ( J:131217 )

• the number of DN1 T cells is increased 5-fold compared to in wild-type mice

increased granulocyte number ( J:131217 )

• the number of Gr-1+Mac1+ cells in the spleen and bone marrow is increased compared to in wild-type mice

decreased B cell number ( J:131217 )

• the number of B220+CD19+ B cells in the bone marrow and spleen is reduced compared to in wild-type mice

hematopoietic system

decreased double-negative T cell number ( J:131217 )

• the number of DN3 decreased 4-fold compared to in wild-type mice

increased double-negative T cell number ( J:131217 )

• the number of DN1 T cells is increased 5-fold compared to in wild-type mice

increased granulocyte number ( J:131217 )

• the number of Gr-1+Mac1+ cells in the spleen and bone marrow is increased compared to in wild-type mice

decreased B cell number ( J:131217 )

• the number of B220+CD19+ B cells in the bone marrow and spleen is reduced compared to in wild-type mice