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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nkx2-5tm6Rph
targeted mutation 6, Richard P Harvey
MGI:3773737
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/0 		involves: 129S1/Sv * FVB/N MGI:3813456
cx2
 		Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/Tg(DMPK/tetO-EGFP/DMPK)5-313Masm 		involves: 129S1/Sv * FVB/N MGI:3813457


Genotype
MGI:3813456
cx1
Allelic
Composition		 Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm6Rph mutation (0 available); any Nkx2-5 mutation (21 available)
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle relaxation ( J:131302 )
• by 3 weeks of treatment with doxycycline, mice exhibit myotonia

cardiovascular system
prolonged PR interval ( J:131302 )
• at 2 weeks post treatment with doxycycline, mice exhibit a less dramatic increase in PR intervals than in Tg(DMPK/tetO-GFP/DMPK)5-313Masm mice




Genotype
MGI:3813457
cx2
Allelic
Composition		 Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/Tg(DMPK/tetO-EGFP/DMPK)5-313Masm
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm6Rph mutation (0 available); any Nkx2-5 mutation (21 available)
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle relaxation ( J:131302 )
• within 2 weeks of treatment with doxycycline, mice develop myotonia

cardiovascular system
abnormal atrioventricular node conduction ( J:131302 )
• within 2 weeks of treatment with doxycycline, mice develop progressive heart block




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory