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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myocdtm1.1Msp
targeted mutation 1.1, Michael S Parmacek
MGI:3773718
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myocdtm1.1Msp/Myocdtm1.1Msp involves: 129/Sv * C57BL/6 MGI:3797649
ht2
 		Myocdem1Blk/Myocdtm1.1Msp involves: 129 MGI:6450809
cx3
 		Myocdtm1.1Msp/mgb involves: 129/Sv * FVB/N MGI:6450805


Genotype
MGI:3797649
hm1
Allelic
Composition		 Myocdtm1.1Msp/Myocdtm1.1Msp
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myocdtm1.1Msp mutation (0 available); any Myocd mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:131288 )
• homozygotes survive only until E10.5-11.5 and recapitulate the phenotype of other Myocd null mice




Genotype
MGI:6450809
ht2
Allelic
Composition		 Myocdem1Blk/Myocdtm1.1Msp
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myocdem1Blk mutation (0 available); any Myocd mutation (55 available)
Myocdtm1.1Msp mutation (0 available); any Myocd mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:283803 )
• unlike mice homozygous for Myocd tm1.1Msp, mice survive to birth but die by 1 week of age

renal/urinary system
abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )
• little or no smooth muscle in the bladder wall
distended urinary bladder ( J:283803 )
• grossly dilated bladder at P1

cardiovascular system
cardiovascular system phenotype ( J:283803 )
N
• no gross cardiac defects

muscle
abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )
• little or no smooth muscle in the bladder wall

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
congenital megabladder DOID:0112014 OMIM:618719
 J:283803




Genotype
MGI:6450805
cx3
Allelic
Composition		 Myocdtm1.1Msp/mgb
Genetic
Background		 involves: 129/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
mgb mutation (0 available); any mgb mutation (0 available)
Myocdtm1.1Msp mutation (0 available); any Myocd mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:283803 )
• die within 1 week of birth

cardiovascular system
patent ductus arteriosus ( J:283803 )
• in newborns

renal/urinary system
distended urinary bladder ( J:283803 )
• grossly dilated bladders

cellular
patent ductus arteriosus ( J:283803 )
• in newborns

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
congenital megabladder DOID:0112014 OMIM:618719
 J:283803




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory