Phenotypes associated with this allele

• Allele Symbol: Ednra^{tm3(Ednrb)Hku}
• Allele Name: targeted mutation 3, Hiroki Kurihara
• Allele ID: MGI:3773700
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednra^tm3(Ednrb)Hku/Ednra^tm3(Ednrb)Hku	involves: 129 * C57BL/6 * ICR	MGI:3796527
ht2	Ednra^tm2.1Hku/Ednra^tm3(Ednrb)Hku	involves: 129 * C57BL/6 * ICR	MGI:3796526
ht3	Ednra^tm1Hku/Ednra^tm3(Ednrb)Hku	involves: 129 * C57BL/6 * ICR	MGI:3796529
ht4	Ednra^tm2Hku/Ednra^tm3(Ednrb)Hku	involves: 129 * C57BL/6 * ICR	MGI:3836980

Genotype
MGI:3796527

hm1

• Allelic Composition: Ednra^{tm3(Ednrb)Hku}/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

Genotype
MGI:3796526

ht2

• Allelic Composition: Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

Genotype
MGI:3796529

ht3

• Allelic Composition: Ednra^tm1Hku/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

Genotype
MGI:3836980

ht4

• Allelic Composition: Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

abnormal hyoid bone morphology ( J:131382 )

abnormal mandible morphology ( J:131382 )

skeleton

abnormal craniofacial bone morphology ( J:131382 )

abnormal hyoid bone morphology ( J:131382 )

abnormal mandible morphology ( J:131382 )