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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glipr1tm1Tt
targeted mutation 1, Timothy C Thompson
MGI:3773696
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glipr1tm1Tt/Glipr1tm1Tt Not Specified MGI:3807669
ht2
 		Glipr1tm1Tt/Glipr1+ Not Specified MGI:3807668
cx3
 		Glipr1tm1Tt/Glipr1+
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd MGI:3807670
cx4
 		Glipr1tm1Tt/Glipr1tm1Tt
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd MGI:3807671


Genotype
MGI:3807669
hm1
Allelic
Composition		 Glipr1tm1Tt/Glipr1tm1Tt
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to alkylating agents ( J:131419 )
• embryonic fibroblasts have reduced levels of apoptosis when treated with DNA damaging agents compared to wild-type embryonic fibroblasts

neoplasm
increased tumor incidence ( J:131419 )
• 10 out of 24 mice develop tumors compared to 1 out of 16 in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Genotype
MGI:3807668
ht2
Allelic
Composition		 Glipr1tm1Tt/Glipr1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:131419 )
• 16 out of 40 mice develop tumors compared to 1 out of 16 in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Genotype
MGI:3807670
cx3
Allelic
Composition		 Glipr1tm1Tt/Glipr1+
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:131419 )
• 59 out of 104 mice develop tumors compared to 31 out of 63 mice in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Genotype
MGI:3807671
cx4
Allelic
Composition		 Glipr1tm1Tt/Glipr1tm1Tt
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:131419 )
• 45 out of 74 mice develop tumors compared to 31 out of 63 mice in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory