About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ier3tm1Raku
targeted mutation 1, Rajiv Kumar
MGI:3773690
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ier3tm1Raku/Ier3tm1Raku involves: 129S6/SvEvTac MGI:3783743


Genotype
MGI:3783743
hm1
Allelic
Composition		 Ier3tm1Raku/Ier3tm1Raku
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ier3tm1Raku mutation (1 available); any Ier3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial fiber size ( J:131099 )
• significantly greater myofibril diameter in cardiomyocyte
heart left ventricle hypertrophy ( J:131099 )
• an increase in left ventricular diameter and mass
decreased heart left ventricle muscle contractility ( J:131099 )
• fractional shortening and left ventricular ejection fraction were reduced
increased systemic arterial blood pressure ( J:131099 )
• 8 weeks old homozygous mice had elevations of systemic arterial pressure

muscle
increased myocardial fiber size ( J:131099 )
• significantly greater myofibril diameter in cardiomyocyte
heart left ventricle hypertrophy ( J:131099 )
• an increase in left ventricular diameter and mass
decreased heart left ventricle muscle contractility ( J:131099 )
• fractional shortening and left ventricular ejection fraction were reduced

growth/size/body
heart left ventricle hypertrophy ( J:131099 )
• an increase in left ventricular diameter and mass




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory