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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atrnl1tm1Gsb
targeted mutation 1, Gregory S Barsh
MGI:3773080
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atrnl1tm1Gsb/Atrnl1tm1Gsb involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ MGI:3773147
cx2
 		Atrnmg-3J/Atrnmg-3J
Atrnl1tm1Gsb/Atrnl1tm1Gsb 		involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ MGI:3773151


Genotype
MGI:3773147
hm1
Allelic
Composition		 Atrnl1tm1Gsb/Atrnl1tm1Gsb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnl1tm1Gsb mutation (0 available); any Atrnl1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:130463 )
N
• mice display normal brain morphology unlike mice with other alleles of Atrn1

integument
integument phenotype ( J:130463 )
N
• unlike Atrnmg-3J homozygotes, mice display a wild-type coat color on an Agouti background




Genotype
MGI:3773151
cx2
Allelic
Composition		 Atrnmg-3J/Atrnmg-3J
Atrnl1tm1Gsb/Atrnl1tm1Gsb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnl1tm1Gsb mutation (0 available); any Atrnl1 mutation (72 available)
Atrnmg-3J mutation (2 available); any Atrn mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:130463 )
• mice develop progressive vacuolation of the brain similar to Atrnmg-3J homozygotes

cardiovascular system
cardiomyopathy ( J:130463 )
• by 6 months of age some mice develop cardiomyopathy

muscle
cardiomyopathy ( J:130463 )
• by 6 months of age some mice develop cardiomyopathy




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory