Phenotypes associated with this allele

• Allele Symbol: Trim63^tm1Slbt
• Allele Name: targeted mutation 1, Siegfried Labeit
• Allele ID: MGI:3773034
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim63^tm1Slbt/Trim63^tm1Slbt	involves: 129 * C57BL/6	MGI:3773040
cx2	Trim55^tm1Slbt/Trim55^tm1Slbt Trim63^tm1Slbt/Trim63^tm1Slbt	involves: 129 * C57BL/6	MGI:3773038

Genotype
MGI:3773040

hm1

• Allelic Composition: Trim63^tm1Slbt/Trim63^tm1Slbt
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:130921 )

• heart weight to body weight is increased 10% compared to in wild-type mice

cardiac hypertrophy ( J:130921 )

• 24.5% of adult mice exhibit cardiac hypertrophy

muscle

increased quadriceps weight ( J:130921 )

• quadriceps weight to body weight is increased 9% compared to in wild-type mice

increased skeletal muscle fiber size ( J:130921 )

• mice exhibit hypertrophy of skeletal muscles and hypertrophy of individual muscle fibers

limbs/digits/tail

increased quadriceps weight ( J:130921 )

• quadriceps weight to body weight is increased 9% compared to in wild-type mice

growth/size/body

increased heart weight ( J:130921 )

• heart weight to body weight is increased 10% compared to in wild-type mice

cardiac hypertrophy ( J:130921 )

• 24.5% of adult mice exhibit cardiac hypertrophy

Genotype
MGI:3773038

cx2

• Allelic Composition: Trim55^tm1Slbt/Trim55^tm1Slbt; Trim63^tm1Slbt/Trim63^tm1Slbt
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:130921 )

• 74% of mice die between the first 7 to 16 days of life likely due to chronic heart insufficiency and acute cardiac decompression with heart failure

cardiovascular system

abnormal myocardium layer morphology ( J:130921 )

• mice exhibit concentric-type hypertrophy of the myocardium

abnormal myocardial fiber morphology ( J:130921 )

• mice exhibit 59% enlarged myocytes and 58% enlarged nuclei

• z-disks in the myocardium are electron dense and less regular than in wild-type mice and occasionally myofibrils have free ends unlike in wild-type mice

• mitochondria within the myocardium are less regular in shape and less orderly packed in addition to vacuoles embedded in mitochondrial clusters not observed in wild-type mice

enlarged heart ( J:130921 )

• mice exhibit an enlarged heart that fills the entire mediastinum

increased heart weight ( J:130921 )

• heart weight to body weight is increased 231% compared to wild-type

cardiac hypertrophy ( J:130921 )

• 84% of mice that survive past weaning exhibit cardiac hypertrophy

decreased cardiac stroke volume ( J:130921 )

• in adult mice, stroke volume is decreased 26% compared to in wild-type mice

hemorrhage ( J:130921 )

• mice exhibit microbleeds when examined post-mortem

decreased cardiac muscle contractility ( J:130921 )

• in adult mice, ejection fraction is reduced 0.2 to 0.3 compared to 0.7 in wild-type mice

muscle

abnormal myocardium layer morphology ( J:130921 )

• mice exhibit concentric-type hypertrophy of the myocardium

abnormal myocardial fiber morphology ( J:130921 )

• mice exhibit 59% enlarged myocytes and 58% enlarged nuclei

• z-disks in the myocardium are electron dense and less regular than in wild-type mice and occasionally myofibrils have free ends unlike in wild-type mice

• mitochondria within the myocardium are less regular in shape and less orderly packed in addition to vacuoles embedded in mitochondrial clusters not observed in wild-type mice

decreased cardiac muscle contractility ( J:130921 )

• in adult mice, ejection fraction is reduced 0.2 to 0.3 compared to 0.7 in wild-type mice

increased quadriceps weight ( J:130921 )

• quadriceps weight to body weight is increased 38% compared to in wild-type mice

abnormal Z line morphology ( J:130921 )

• z-disks in the myocardium are electron dense and less regular than in wild-type mice and occasionally myofibrils have free ends unlike in wild-type mice

respiratory system

abnormal lung morphology ( J:130921 )

• post-mortem mice display partial compression of the lungs and effacement of the alveolar cells

pulmonary edema ( J:130921 )

• post-mortem mice display acute edema in the lungs with compression of neighboring organs

liver/biliary system

abnormal liver morphology ( J:130921 )

• post-mortem livers appear hyperemic

growth/size/body

enlarged heart ( J:130921 )

• mice exhibit an enlarged heart that fills the entire mediastinum

increased heart weight ( J:130921 )

• heart weight to body weight is increased 231% compared to wild-type

cardiac hypertrophy ( J:130921 )

• 84% of mice that survive past weaning exhibit cardiac hypertrophy

slow postnatal weight gain ( J:130921 )

• mice fail gain weight at the same rate as wild-type mice and become progressively underweight

adipose tissue

decreased total body fat amount ( J:130921 )

• mice exhibit a decrease in fat accumulation compared to wild-type mice

homeostasis/metabolism

abnormal cardiac thrombosis ( J:130921 )

• mice exhibit microthrombi in the heart when examined post-mortem but no areas of necrosis or signs of fibrosis

pulmonary edema ( J:130921 )

• post-mortem mice display acute edema in the lungs with compression of neighboring organs

limbs/digits/tail

increased quadriceps weight ( J:130921 )

• quadriceps weight to body weight is increased 38% compared to in wild-type mice