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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Robo1tm1Wian
targeted mutation 1, William Andrews
MGI:3772898
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Robo1tm1Wian/Robo1tm1Wian involves: 129S/SvEv MGI:5754356
hm2
 		Robo1tm1Wian/Robo1tm1Wian involves: 129S/SvEv * C57BL/6 MGI:3772914


Genotype
MGI:5754356
hm1
Allelic
Composition		 Robo1tm1Wian/Robo1tm1Wian
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1tm1Wian mutation (0 available); any Robo1 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
perimembraneous ventricular septal defect ( J:244438 )
• mice exhibit perimembranous VSDs at E18.5, just before birth




Genotype
MGI:3772914
hm2
Allelic
Composition		 Robo1tm1Wian/Robo1tm1Wian
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1tm1Wian mutation (0 available); any Robo1 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic/fetal subventricular zone morphology ( J:130430 )
• cell cultures of ganglionic eminence exhibit increased cell proliferation compared to wild-type cells
abnormal neurite morphology ( J:130430 )
• in the subventricular zone/intermediate zone and subplate, mic exhibit an increased in neurite process length is, the number of neurites, and the degree of branching




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory