Phenotypes associated with this allele

• Allele Symbol: Bnc1^tm1.1Tsen
• Allele Name: targeted mutation 1.1, Hung Tseng
• Allele ID: MGI:3771811
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bnc1^tm1.1Tsen/Bnc1^tm1.1Tsen	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3771813

Genotype
MGI:3771813

hm1

• Allelic Composition: Bnc1^tm1.1Tsen/Bnc1^tm1.1Tsen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal corneal wound healing ( J:130266 )

• corneal epithelium wound area is 3 times larger at 40 hours after injury and 6 times larger at 72 hours compared to in wild-type mice due to a delay in increased proliferation of epithelial cells

decreased corneal epithelium thickness ( J:130266 )

• mice exhibit a 14% thinning of the corneal epithelium (30.6 microns compared to 34.6 microns in wild-type mice)

corneal epithelium hypoplasia ( J:130266 )

• 15% fewer cells are present in the corneal epithelium (cell density of 116+/-8 cells per 0.3 um length compared to 139+/-11 in wild-type mice)

• cell proliferation in the corneal epithelium is decreased 25% (135+/-25 Ki67+ cells per section compared to 181+/-17 in wild-type mice)

• however, apoptosis rates are normal in the corneal epithelium

homeostasis/metabolism

abnormal corneal wound healing ( J:130266 )

• corneal epithelium wound area is 3 times larger at 40 hours after injury and 6 times larger at 72 hours compared to in wild-type mice due to a delay in increased proliferation of epithelial cells