Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1tm1Nca mutation
(0 available);
any
Slc40a1 mutation
(53 available)
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mortality/aging
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• almost all embryos die by E7.5 with only one embryo found at E7.5 and one found at E8.5
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embryo
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• at E7.0 embryos are significantly smaller than heterozygous and wild-type littermates
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growth/size/body
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• at E7.0 embryos are significantly smaller than heterozygous and wild-type littermates
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Allelic
Composition |
Slc40a1tm1Nca/Slc40a1+
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Genetic
Background |
involves: 129S4/SvJae * 129S6/SvEvTac |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1tm1Nca mutation
(0 available);
any
Slc40a1 mutation
(53 available)
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hematopoietic system
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N |
• at 3 and 6 months of age mice are not anemic despite disrupted iron homeostasis
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• at 6 months of age, reticulocytes and mature erythrocytes have reduced cellular hemoglobin
• at 12 months of age hemoglobin content of erythrocytes remains reduced compared to wild-type controls
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• at 6 months of age, reticulocytes and mature erythrocytes have reduced cell volume
• at 12 months of age mean cell volume of erythrocytes remains reduced compared to wild-type controls
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• at 12 months of age spleen iron content is increased compared to controls
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homeostasis/metabolism
immune system
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• at 12 months of age spleen iron content is increased compared to controls
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liver/biliary system
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• significant reduction in liver non-heme iron at 6 and 12 months of age
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Analysis Tools