Phenotypes associated with this allele

• Allele Symbol: Wnk4^tm1Suc
• Allele Name: targeted mutation 1, Shinichi Uchida
• Allele ID: MGI:3771073
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Wnk4^tm1Suc/Wnk4^+	involves: 129S4/SvJae * C57BL/6	MGI:3771076

Genotype
MGI:3771076

ht1

• Allelic Composition: Wnk4^tm1Suc/Wnk4⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating bicarbonate level ( J:129716 )

• at 3.5 months, 19.9+/-1.5 mmol/l compared to 23.6+/-1.4 mmol/l in wild-type mice

increased circulating potassium level ( J:129716 )

• at 1.5 months, 4.2+/-0.4 mmol/l compared to 3.9+/-0.3 mmol/l in wild-type mice

• at 3.5 months, 4.9+/-0.5 mmol/l compared to 4.0+/-0.3 mmol/l in wild-type mice

decreased urine potassium level ( J:129716 )

• 9.1+/-2.8% compared to 11.9+/-1.5% in wild-type mice

acidosis ( J:129716 )

• at 3.5 months, pH of 7.26+/-0.04 compared to pH 7.31+/-0.05 in wild mice

cardiovascular system

hypertension ( J:129716 )

• at 3.5 months, systolic blood pressure is 142.3+/-9.1 mm Hg compared to 119.6+/-6.6 mmHg in wild-type mice

• however, dietary restriction of sodium improves blood pressure measurements

renal/urinary system

decreased urine potassium level ( J:129716 )

• 9.1+/-2.8% compared to 11.9+/-1.5% in wild-type mice