About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pycardtm1Nnz
targeted mutation 1, Gabriel Nunez
MGI:3771030
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pycardtm1Nnz/Pycardtm1Nnz involves: 129 * C57BL/6 MGI:3771034


Genotype
MGI:3771034
hm1
Allelic
Composition		 Pycardtm1Nnz/Pycardtm1Nnz
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Nnz mutation (0 available); any Pycard mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:129871 )
• peritoneal macrophages or dendritic cells fail to secrete IL-1beta in response to Listeria infection
• peritoneal macrophages have reduced secretion of IL-1beta in response to a TLR2 agonist
decreased interleukin-18 secretion ( J:129871 )
• peritoneal macrophages have reduced secretion of IL-1beta in response to a TLR2 agonist




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory